I had noticed this salon off and on for a number of years. It was what I took to be an office strip mall on Two Notch Road near Very's and across the road from Dentsville Baptist Church. I noticed earlier this month that it had closed up, but when I stopped to take some pictures of it, I found that the "strip mall", Dentsville Office Mall was actually more interesting.
I had never realized it, but it's obvious once you go back into the parking lot for the place that it used to be one of the many US 1 roadside motels in Columbia. The old guest rooms form a "U" shaped court with a two story Office/Lobby in the center. I don't know what it was called as a motel, or exactly when it closed, but you can tell from a couple of these shots something that was confirmed by a gentleman who came out to chat with me: The grassy plot in front is actually the former swimming pool area. Once you know it was a motel, even the main sign looks like it's a 50s design with the panels relabeled.
As you can also see here, some of the guest rooms behind Touch of Joy have been fire damaged in recent years, and the plan is apparently to convert them into a number of self-storage units rather than try to restore the old hotel electrical and plumbing in that area. The rest of the mall seems to be "destination" businesses which don't rely on high street visibility: A tax service, a dental lab and and an alteration shop. It's a nice little bit of history I never noticed before.