Moxie's / The Cork & Cleaver / Cobblestone (?) / John Paul's Steakhouse / D. B. Hooter's / CJ's (?) / D's Wings, 806 Saint Andrews Road: Early 2008 19 comments
D's is a local (I believe) chain of casual restaurants with an unusually large menu. They have a little something for everyone, and are the only restaurants in Columbia (that I know of) which fry their own potato chips ("raw fries" they call them). They have a number of locations; I can think of Clemson Road, Parkland Plaza, and Beltline Blvd. They now have one less.
This particular building on St. Andrews Road appears to have a restaurant curse attached to it, as I have seen a number of operations go into it over the years, and none of them have lasted very long. More prosaically, it may just be that while it is easy to exit I-26 to eat there, it is difficult to get back on the Interstate because a left turn out of the parking lot is almost impossible when traffic is moderate or heavy.
UPDATE 24 Feb 2010: Added a bunch of previous names to the post title based on the comments. Also see here (Baja's Southwestern Grill) and here (Delmonico Diner) for the next two operations in this building.
UPDATE 31 Jan 2011: Added the full street address to the post title, finally.