Nice 'N Natural, located on College Street in between Main and Sumter Streets (and next to the former USC Burger King) shares an attractive old brick building with Cool Beans coffe shop. It's within easy walking distance from The Horseshoe, and in general, I have found parking in the area to be reasonably easy, at least in the evenings.
I mention evening, because I must admit that while I've been to Cool Beans numerous times over the years, I never made it to Nice 'N Natural. I was kind of vaguely aware it was there, but I was never in the area during its open hours, and had the tenuous impression from the name that it was a "healthy" place (ie: not something that would be high on my list). The Free Times brief description sort of re-inforces that impression, though "whole grain" attracts me more than "alfalfa sprouts".
I think I read in The State a week or so back that the owners reported that business fell off after 9-11 and never really recovered. If that be the case, then they've hung on for 10 bad years, which is certainly something to be proud of (and of course their 28 years is an extraordinary run for any restaurant).