Apparently this building, on the South side of Knox Abbott Drive, just below the Crazy Buffett, has a history in financial services.
As is often the case in vacant buildings with custom signs, the existing sign is turned around in the display. I guess this is done to keep the elements out of the display box, at any rate I've seen these reversed signs many times since I started this blog. Anyway, this sign indicates that financial services company Amerifirst Direct once operated here. That would have been before 2008 when Citifancinal is listed in the phonebook for that slot.
Citifinancial either closed or moved during 2008 as it is gone from the 2009 phonebook (There is still a Citi office on Knox Abbott, but I don't know if it is the same operation or a separate one).
UPDATE 28 June 2016 -- Now a State Farm office: