You get a very inaccurate idea of what bus travel is when you take class trips. When I was in middle and high school, our long class trips (Washington DC and Disney World were the most notable) were done on chartered Trailways buses, and the administration always requested, and got, the same kid-friendly driver. When the bus is filled with your friends and classmates, the ride is almost part of the attraction.
I've never actually ridden a scheduled long-haul bus as a party of one, but from seeing the Trailways stations and the people in them on rest-breaks during those class trips and from talking with aunts and cousins, I think I have a pretty good idea that, unfortunately, the "scum of the earth" passengers make life very unpleasant for the "salt of the earth" ones, and that the novelty of having a bathroom in a land vehicle is rather eclipsed by the horror of having it overflow.
What that adds up to saying is that I never took a bus at the Greyhound station downtown, but we did wait there once to pick up my aunt from Florida (she never did it again), and once to see off a cousin. I was fascinated by the Art Deco look, and by all of those glass blocks. I don't suppose it was any nicer than the more newly built stations inside, but sometime after this was built, US architects forgot how to design good looking buildings.
Wikipedia has a great very high-res shot here and says the station was built in 1938 & 1939 with Grehound moving out in 1987. That's about what I remembered. Apparently the building is a doctor's office now.
If you look up above the station, in some of these shots you can see another Columbia icon as well.