Home Furniture in Irmo closed in late September. To the best of my recollection, I had never been on the segment of Lake Murray Boulevard below Columbiana Drive before, and there was a lot more development there than my memories of visiting the Lake Murray area 30 years ago would have led me to expect.
According to this PDF though, Home Furniture had been around a lot longer than 30 years ( and a lot longer than I have for that matter!) -- 63 years. Also, from the PDF, it appears that they had a temporary closing back in January 2010 so the original owner could retire. Assuming those plans went through, I'm guessing the continuing housing slump kept the store from coming back full strength after the transition. At any rate, this closing seems to be final, unfortunately -- the electronic sign was cycling through an offer to lease the building along with the closure notice.
(Hat tip to commenter Andrew)
UPDATE 14 July 2014: Commenter Andrew points to this story in The State saying that Home Furniture is open again. I have updated the post title to reflect that.